FP465INTENSIVE MONITORING OF POST FILTER IONIZED CALCIUM CONCENTRATIONS DURING CVVHD WITH REGIONAL CITRATE ANTICOAGULATION

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Regional citrate anticoagulation for continuous renal replacement therapy without post-filter monitoring of ionized calcium

*Corresponding author: Tibor Fülöp, M.D., FACP, FASN, Division of Nephrology, University of Mississippi Medical Center, 2500 North State Street, L 504; Jackson, Mississippi 39216-4505. Present address of corresponding author: Department of Medicine Division of Nephrology, Medical University of South Carolina, Charleston, USA, Email: [email protected] http://journalrip.com DOI: 10.1517...

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Discrepant post filter ionized calcium concentrations by common blood gas analyzers in CRRT using regional citrate anticoagulation

INTRODUCTION Ionized calcium (iCa) concentration is often used in critical care and measured using blood gas analyzers at the point of care. Controlling and adjusting regional citrate anticoagulation (RCA) for continuous renal replacement therapy (CRRT) involves measuring the iCa concentration in two samples: systemic with physiological iCa concentrations and post filter samples with very low i...

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Optimizing citrate dose for regional anticoagulation in continuous renal replacement therapy: measuring citrate concentrations instead of ionized calcium?

Regular measurement of systemic and post-filter ionized calcium (iCa) concentrations is imperative to correctly handle regional citrate anticoagulation dose during continuous renal replacement therapy (CRRT). Keeping post-filter iCa within a tight range guarantees optimal circuit function and enhances filter life span [1, 2], whereas a decrease in plasma iCa, with subsequent elevation of the to...

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Ionized calcium measurements during regional citrate anticoagulation in CRRT: we need better blood gas analyzers.

Schwarzer et al. [1] showed discrepant postfilter ionized calcium concentrations [iCa] when using different blood gas analyzers (BGAs) and called for a change of the Fresenius regional citrate anticoagulation (RCA) protocol to ensure patient safety. Of note, precision of the BGAs was not tested. In our opinion, the key message of their study is that commercially available BGAs are not accurate ...

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Citrate pharmacokinetics and calcium levels during high-flux dialysis with regional citrate anticoagulation

BACKGROUND Regional citrate anticoagulation is a very effective anticoagulation method for haemodialysis. However, it is not widely used, primarily due to the risk of hypocalcaemia. We studied citrate and calcium kinetics to better understand safety aspects of this anticoagulation method. METHODS During 15 haemodialysis treatments with a calcium-free dialysis solution, citrate was infused pre...

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ژورنال

عنوان ژورنال: Nephrology Dialysis Transplantation

سال: 2018

ISSN: 0931-0509,1460-2385

DOI: 10.1093/ndt/gfy104.fp465